Table 15.

Recommendations for pharmacotherapy for panic disorder

First-line	Citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, paroxetine CR, sertraline, venlafaxine XR
Second-line	Alprazolam, clomipramine, clonazepam, diazepam, imipramine, lorazepam, mirtazapine, reboxetine
Third-line	Bupropion SR, divalproex, duloxetine, gabapentin, levetiracetam, milnacipran, moclobemide, olanzapine, phenelzine, quetiapine, risperidone, tranylcypromine
Adjunctive therapy	Second-line: alprazolam ODT, clonazepam Third-line: aripiprazole, divalproex, olanzapine, pindolol, risperidone
Not recommended	Buspirone, propranolol, tiagabine, trazodone

CR = controlled release; ODT = orally disintegrating tablets; SR = sustained release; XR = extended release.