Table 30.

Recommendations for pharmacotherapy for core symptoms of PTSD

First-line	Fluoxetine, paroxetine, sertraline, venlafaxine XR
Second-line	Fluvoxamine, mirtazapine, phenelzine
Third-line	Amitriptyline, aripiprazole, bupropion SR, buspirone, carbamazepine, desipramine, duloxetine, escitalopram, imipramine, lamotrigine, memantine, moclobemide, quetiapine, reboxetine, risperidone, tianeptine, topiramate, trazodone
Adjunctive therapy	Second-line: eszopiclone, olanzapine, risperidone Third-line: aripiprazole, clonidine, gabapentin, levetiracetam, pregabalin, quetiapine, reboxetine, tiagabine Not recommended: bupropion SR, guanfacine, topiramate, zolpidem
Not recommended	Alprazolam, citalopram, clonazepam, desipramine, divalproex, olanzapine, tiagabine

SR = sustained release; XR = extended release.