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. Author manuscript; available in PMC: 2014 Aug 4.
Published in final edited form as: Annu Rev Genomics Hum Genet. 2011;12:301–325. doi: 10.1146/annurev-genom-082410-101440

Figure 1. PD gene product domains and pathogenic mutations.

Figure 1

Domains are arranged from N- to C- termini. For LRRK2: Ank (Ankyrin-like repeats); LRR (leucine-rich repeats); ROC (Ras of complex GTPase domain); COR (C-terminal of ROC); Kinase and WD40. PINK1: MTS (mitochondrial targeting sequence); TM (putative transmembrane domain); and serine/threonine kinase. For Parkin: UBL (ubiquitin-like) and two RING domains separated by an IBR (in-between RING) domain. α-synuclein has a number of imperfect KTKEGV repeat sequences (white stripes) in the N-terminal region and central NAC (non-amyloid component) region. DJ-1 is a single domain protein. Numbers under the protein indicate domain boundaries. Mutations that segregate with PD are annotated at their approximate position along the protein’s length.