Table 1.

Genes and loci associated with Parkinsonism

PARK locus	Gene	Map position	Clinical phenotype	Pathology
PARK1/4	SNCA	4q21	Parkinsonism with common dementia	Lewy bodies
PARK2	Parkin	6q25-q27	Early-onset, slowly progressing Parkinsonism	Lewy bodies rarely
PARK3	Unknown	2p13	Late-onset Parkinsonism	Lewy bodies
PARK5	UCHL1	4p14	Late-onset Parkinsonism	Unknown
PARK6	PINK1	1p35-p36	Early-onset, slowly progressing Parkinsonism	One case exhibiting Lewy bodies
PARK7	DJ-1	1p36	Early-onset Parkinsonism	Unknown
PARK8	LRRK2	12q12	Late-onset Parkinsonism	Usually Lewy bodies
PARK9	ATP13A2	1p36	Early-onset Parkinsonism with Kufor-Rakeb syndrome	Unknown
PARK10	Unknown	1p32	Unclear	Unknown
PARK11	GIGYF2	2q36-q37	Late-onset Parkinsonism	Unknown
PARK12	Unknown	Xq	Unclear	Unknown
PARK13	Omi/HTRA2	2p13	Unclear	Unknown
PARK14	PLA2G6	22q13.1	Parkinsonism with additional features	Lewy bodies
PARK15	FBX07	22q12-q13	Early-onset Parkinsonism	Unknown
PARK16?	Unknown	1q32	Late-onset Parkinsonism	Unknown
FTDP-17	MAPT	17q21.1	Dementia, sometimes Parkinsonism	Neurofibrillary Tangles
SCA2	Ataxin 2	12q24.1	Usually ataxia, sometimes Parkinsonism	Unknown
SCA3	Ataxin 3	14q21	Usually ataxia, sometimes Parkinsonism	Unknown
Gaucher’s locus	GBA	1q21	Late-onset Parkinsonism	Lewy bodies