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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: J Mol Cell Cardiol. 2014 May 10;74:139–150. doi: 10.1016/j.yjmcc.2014.05.001

Fig. 8.

Fig. 8

Effects of miR-320-reduced exosomes collected form miR-320-off GK cardiomyocytes on angiogenesis. (A) Infection of GK-cardiomyocytes with Ad.miR-320-off dramatically reduced miR-320 levels in cardiomyocytes and their released exosomes. (B) Protein levels of Hsp20 were remarkably increased in Ad.miR-320-off-infected GK myocytes and their released exosomes. n = 4, *p < 0.05 vs. controls indicated. miR-320-off-exosomes (20 μg/ml) significantly promoted (C) MCEC migration and (D) tube-like formation, compared with miR-off control exosomes. Total capillary tube length was measured as described in Fig. 3. All values were expressed as means ± SD; *p < 0.05 vs. medium controls. Similar results were observed in three additional, independent experiments. (E) Proposed scheme for cardiomyocyte-mediated anti-angiogenesis through exosomal miR-320 in diabetic hearts.