Table 1.

Coordinates used to generate a priori regions of interest (ROIs). A) Coordinates of treatment related decreases in the subgenual cingulate tied to antidepressant effect, the treatment modality used, and the average coordinates used to generate our a priori ROI. B) Coordinates of various left dorsal-lateral prefrontal cortex transcranial magnetic stimulation targets suggested in the literature. For all prior studies we show the published coordinates in either Talairach (Tx, Ty, Tz) or MNI (MNIx, MNIy, MNIz) space along with the transformed MNI coordinates used in the present study.

A) SUBGENUAL REGION
Study	Tx	Ty	Tz	MNIx	MNIy	MNIz	Treatment
Wu et al. 1999	7	17	−4	7	18	−4	Sleep Deprivation
Mayberg et al. 2000	4	2	−4	4	2	−5	SSRI
Drevets et al. 2002	3	31	−10	3	32	−10	SSRI
Mayberg et al. 2005	−2	8	−10	−2	9	−11	DBS
Mayberg et al. 2005	10	20	−4	10	21	−4	DBS
Kito et al. 2008	17	16	−14	17	17	−16	TMS
Kito et al. 2011	8	21	−9	8	22	−9	TMS
Nahas et al. 2007	0	8	−16	0	9	−19	VNS
AVERAGE				5.9	16.3	−9.8
B) DLPFC REGIONS
Study / Site	Tx	Ty	Tz	MNIx	MNIy	MNIz
Herwig 2001 5cm Stim. Site	−42	17	52
Herbsman 2009 5cm Stim. Site	−42	20	49
Herbsman 2009 5cm Sham Site	−39	17	47
AVERAGE 5cm Coordinates	−41	18	49	−41	16	54
Herbsman 2009 Responders	−46	25	44	−46	23	49
Herbsman 2009 Nonresponders	−41	19	50	−41	17	55
Herwig 2003 EEG (F3) Site	−37	27	44	−37	26	49
Rajkowska 1995 BA46 Definition	−44	40	25	−44	40	29
Rajkowska 1995 BA9 Definition	−36	40	38	−36	39	43
Paus 2001 TMS Target	−40	32	30	−40	31	34
Cho 2009 TMS Target	−40	32	30	−40	31	34
Fitgerald 2009 TMS Target	−46	45	35	−46	45	38
Rusjan 2010 TMS Target	−50	31	32	−50	30	36