Table 4.
Acral lentiginous/ mucosal melanoma cases positive for KIT mutation
| Case | Diagnosis | Kit mutation | KIT IHC (%) | KIT IHC (intensity) |
|---|---|---|---|---|
| 28 | AL, primary, left foot | Exon 11, L576P | 5–50 | 1+ |
| 46 | AL, primary, left foot | Exon 17, D816V | 51–95 | 3+ |
| 82 | AL, primary, left foot | Exon 11, 566 to 572 del | 5–50 | 1+ |
| 52 | AL, met, inguinal LN (left foot primary) | Exon 13, N655K | >95 | 3+ |
| 60 | AL, met, skin (left toe primary) 1 | Exon 11, V559Aa | 51–95 | 2+ |
| 6 | Muc, primary, anus/rectuma | Exon 11, V560Da | 51–95 | 3+ |
| 10 | Muc, primary, vulva | Exon 11, L576P | 51–95 | 3+ |
| 20 | Muc, primary, vaginaa | Exon 17, D816Va | 51–95 | 2+ |
| 38 | Muc, primary, conjunctiva | Exon 11, V559G | >95 | 2+ |
| 88 | Muc, primary, palate | Exon 11, 566 to 574 del | 51–95 | 2+ |
| 120 | Muc, primary, anus/rectum | Exon 11, L576P | >95 | 3+ |
| 127 | Muc, primary, vulva | Exon 13 (K642E) and 17 (N822I) | >95 | 2+ |
| 159 | Muc, primary, vulva | Exon 13, K642E | >95 | 3+ |
| 162 | Muc, primary, anus/rectum | Exon 11, L576P | >95 | 3+ |
AL: acral lentiginous; Muc: mucosal; met: metastasis.
a
Mutation analysis performed on both primary and metastatic tumors showed the same genetic defect.