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. 2014 Aug 1;55(8):4691–4699. doi: 10.1167/iovs.14-14133

Figure 5.

Figure 5

The PP1 attenuates EGF-mediated EGFR ubiquitylation and enhances EGFR corneal epithelial wound healing in vitro. A 1.5-mm-diameter wound was generated on the corneal epithelium of a mouse as described in Materials and Methods. Eyes were treated with various combinations of PBS, PP1 (0.01 μM), and EGF (100 ng/mL), as indicated on the figure. Shown are representative photographs from experiments repeated four to five times per condition. (B) Percentage of initial wound that has healed at each time point. Data are plotted as the average ± SEM, n = 4–5 eyes/condition. (C–E) Data from (B) replotted to more clearly show the (C) 16-hour, (D) 24-hour, and (E) 40-hour time points. **P < 0.05; *P < 0.1. Data were analyzed using a two-way ANOVA with a Bonferroni post hoc. Data from AG1478 mice were compared with mice with the same treatment in the absence of AG1478.