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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Neurobiol Dis. 2014 May 27;69:124–133. doi: 10.1016/j.nbd.2014.05.018

Figure 1.

Figure 1

Effects of CCR2-/- bone marrow transplantation on IL-1β-mediated plaque reduction. A, Representative photomicrographs of 6E10 positive Aβ plaques (white) and GFP+ infiltrating cells (green) following IL-1β overexpression in APP/PS1 or APP/PS1-IL-1βXAT mice reconstituted with either WT or CCR2-/- bone marrow. B, Quantitative analysis of mean number of GFP+ cells per plaque in APP/PS1- IL-1βXAT mice (IL-1β overexpressing hemisphere only). C,D, Representative images of 6E10 (C) and Congo red (D) staining of amyloid plaques (black). Scale bar = 100 µm. E,F, Quantitative analysis of 6E10 (E) and Congo red (F) displayed as percent area of hippocampus occupied by plaque. n = 5-8 per group. Data displayed as mean ± SEM, two-way ANOVA, Bonferroni post hoc test, ***p < 0.0001, **p < 0.001, *p < 0.05.