Table 2.
Allele frequencies of rs4986790 (+896A/G) TLR4, rs333 (Δ32) CCR5 deletion, rs2070744 (−786T/C) eNOs, rs1799752 (D/I) ACE, rs3918242 (−1562C/T) MMP-9, and rs2285053 (−735C/T) MMP-2 SNPs in 161 S-TAA patients and 128 matched controls (2 × 2 comparisons between the different groups with odd ratio (OR) and 95% confidence interval).
| Candidate genes | Reference SNP number | Alleles |
Patients (N = 161) |
Matched controls (N = 128) |
P (2 × 2 tables) | OR (95% CI) | ||
|---|---|---|---|---|---|---|---|---|
| TLR4 | rs4986790 | +896A | 321 | 99.7% | 245 | 96% | 0.0008 | 14.4 (18.1–112.4) P = 0.0008 |
| +896G | 1 | 0.3% | 11 | 4% | ||||
|
| ||||||||
| CCR5 | rs333 | WT | 317 | 98% | 238 | 93% | 0.001 | 4.7 (1.7–13.1) P = 0.001 |
|
| ||||||||
| eNOS | rs2070744 | Δ32 | 5 | 2% | 18 | 7% | 0.00007 | 2.2 (1.5–3.2) P < 0.0001 |
| −786T | 207 | 64% | 204 | 80% | ||||
| −786C | 115 | 36% | 52 | 20% | ||||
|
| ||||||||
| ACE | rs1799752 | I | 125 | 39% | 141 | 55% | 0.0001 | 1.9 (1.3–2.6) P = 0.0001 |
| D | 197 | 61% | 115 | 45% | ||||
|
| ||||||||
| MMP-9 | rs3918242 | −1562C | 282 | 88% | 241 | 94% | 0.011 | 2.27 (1.2–4.22) P = 0.01 |
| −1562T | 40 | 12% | 15 | 6% | ||||
|
| ||||||||
| MMP-2 | rs2285053 | −735C | 287 | 89% | 251 | 98% | 0.00005 | 6.1 (2.3–15.8) P < 0.0001 |
| −735T | 35 | 11% | 5 | 2% | ||||
All genotypes were in Hardy-Weinberg equilibrium.