Table 4.
Systemic plasma mediator's levels “AASSP” from patients and controls.
| Systemic mediators examined | Patients (N = 161) |
Controls (N = 128) |
P values∗ |
|---|---|---|---|
| IL-6 (pg/mL) | 13.69 ± 2.1 | 5.1 ± 1.9 | <0.0001 |
| TNF-α (pg/mL) | 16.34 ± 1.2 | 8.1 ± 2.4 | <0.0001 |
| CRP (mg/L) | 16.86 ± 2.2 | 5.6 ± 1.3 | <0.0001 |
| MMP-2 (ng/mL) | 57.5 ± 2.8 | 13.54 ± 1.24 | <0.0001 |
| MMP-9 (ng/mL) | 59.8 ± 2.5 | 12.7 ± 1.6 | <0.0001 |
|
| |||
| Systemic mediators examined | Patients with high responder genotype (N = 46) |
Patients with other genotypes (N = 115) |
P values∗ |
|
| |||
| IL-6 (pg/mL) | 17.66 ± 2.1 | 9.1 ± 0.9 | <0.001 |
| TNF-α (pg/mL) | 16.78 ± 1.2 | 10.1 ± 2.2 | <0.01 |
| CRP (mg/L) | 20.13 ± 1.7 | 12.1 ± 0.5 | 0.01 |
| MMP-2 (ng/mL) | 61.8 ± 3.8 | 26.54 ± 1.6 | <0.0001 |
| MMP-9 (ng/mL) | 59.7 ± 3.7 | 21.7 ± 2.6 | <0.0001 |
|
| |||
| Systemic mediators examined | Patients with high responder genotype (N = 46) |
Controls with high responder genotype (N = 10) |
P values∗ |
|
| |||
| IL-6 (pg/mL) | 17.66 ± 2.1 | 8.66 ± 2.1 | <0.0001 |
| TNF-α (pg/mL) | 16.78 ± 1.2 | 10.78 ± 1.2 | <0.01 |
| CRP (mg/L) | 20.13 ± 1.7 | 6.13 ± 1.7 | <0.0001 |
| MMP-2 (ng/mL) | 61.8 ± 3.8 | 18.8 ± 3.9 | <0.0001 |
| MMP-9 (ng/mL) | 59.7 ± 3.7 | 12.7 ± 2.7 | <0.0001 |
*By unpaired t-test with Welch correction.