Table 5.
Comparison of systemic inflammatory mediator's levels “AASSP” from controls bearing combined risk genotype versus controls with other genotypes and between controls bearing +896A TLR4 allele versus controls with +896G TLR4 allele.
| Systemic mediators examined | Controls with combined risk genotype (N = 10) |
Controls with other genotypes (N = 118) |
P values∗ |
|---|---|---|---|
| IL-6 (pg/mL) | 8.66 ± 2.1 | 1.1 ± 0.69 | <0.0001 |
| TNF-α (pg/mL) | 10.78 ± 1.2 | 2.1 ± 1.2 | <0.0001 |
| CRP (mg/L) | 6.13 ± 1.7 | 0.9 ± 1.5 | <0.0001 |
| MMP-2 (ng/mL) | 18.8 ± 3.9 | 2.54 ± 1.3 | <0.0001 |
| MMP-9 (ng/mL) | 12.7 ± 2.7 | 1.7 ± 1.6 | <0.0001 |
|
| |||
| Systemic mediators examined | Controls with +896ATLR4 allele (N = 10) |
Controls with +896G TLR4 allele (N = 118) |
P values∗ |
|
| |||
| IL-6 (pg/mL) | 5.1 ± 0.9 | 0.9 ± 0.5 | <0.0001 |
| TNF-α (pg/mL) | 7.1 ± 0.6 | 2.1 ± 1.2 | <0.001 |
| CRP (mg/L) | 4.3 ± 1.1 | 0.3 ± 1.9 | <0.0001 |
| MMP-2 (ng/mL) | 10.6 ± 1.8 | 1.8 ± 0.9 | <0.0001 |
| MMP-9 (ng/mL) | 8.3 ± 0.7 | 0.98 ± 1.5 | <0.0001 |
*By unpaired t-test with Welch correction.