Table I.
Demographic information of the study cohort. PMI, pH, and age at death are shown as Mean ± SEM.
| Diagnosis/ Manner of death |
Cohort | Subjects number |
Age at death (years) |
PMI (hr) | Brain pH | Sex | Race | Number of subjects with | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||||
| Antidepressants* | Alcohol use** | Drug use*** | Smoking | ||||||||
| NC | SMRI (Array Collection) | 34 | 43.8 ± 1.3 | 29.5 ± 2.2 | 6.60 ± 0.05 | 25M; 9F | 34W | 0 | 2 | 1 | 5 |
| SMRI; (Depression /SuicideCohort) | 11 | 47.1 ± 3.8 | 25.1 ± 3.4 | 6.62 ± 0.05 | 7 M;4 F | 10W; 1 H | 1 | 4 | 1 | 4 (4 UK) | |
| MBC | 11 | 50.6 ± 5.0 | 18.2 ± 1.3 | 6.66 ± 0.06 | 7 M;4 F | 10W; 1 B | 1 | 2 | 0 | 1 | |
| Total | 56 | 45.8 ± 1.5 | 26.5 ± 1.6 | 6.62 ± 0.03 | 39M;17F | 54W; 1B; 1H | 2 | 8 | 2 | 10 (4 UK) | |
| MDDNoSuic | SMRI; (Depression /Suicide Cohort) | 11 | 44.8 ± 2.3 | 32.6 ± 5.9 | 6.65 ± 0.03 | 7 M;4 F | 11W | 9 | 3 (1 UK) | 2 (1 UK) | 4 (5 UK) |
| MBC | 10 | 44.3 ± 6.3 | 17.0 ± 2.8 | 6.64 ± 0.18 | 6M;4 F | 7W; 3 B | 10 | 3 | 2 | 2 | |
| Total | 21 | 44.6 ± 3.2 | 25.2 ± 3.7 | 6.65 ± 0.06 | 13M; 8F | 18W; 3B | 19 | 6(1 UK) | 4 (1 UK) | 6 (5 UK) | |
| MDDSuic | SMRI; (Depression /Suicide Cohort) | 11 | 41.9 ± 3.4 | 27.5 ± 4.2 | 6.67 ± 0.05 | 7 M; 4 F | 10W; 1 H | 9 | 3 (1 UK) | 2 (1 UK) | 2 (6 UK) |
| MBC | 13 | 44.2 ± 5.3 | 21.8 ± 1.0 | 6.60 ± 0.06 | 9 M; 4 F | 13W | 9 (4 UK) | 4 | 2 (1 UK) | 3 | |
| Total | 24 | 43.2 ± 3.2 | 24.5 ± 2.1 | 6.64 ± 0.04 | 16M; 8F | 23W; 1H | 18 | 7 (1 UK) | 3 (2 UK) | 5 (6 UK) | |
UK, unknown; M, male; F, female; W, white; H, Hispanic; B, Black.
*
Prescribed medications or revealed by toxicology.
**
Heavy use (past or present) for SMRI; abuse/dependence for MBC.
***
Moderate to heavy use (past or present) for SMRI; abuse/dependence for MBC.