Table IV.

Analysis of ADAR1 and ADAR2 mRNA expression by ANCOVA. Comparison between diagnoses (NC vs. MDD) is presented. PMI and age were used as covariates. The expression was assessed using TaqMan assays described in Supplementary Methods, Supplementary Table 3, and Supplementary Figure 1, all available online. The expression of target transcripts was normalized to geometric mean of five endogenous controls (B2M, GUSB, PPIA, RPLPO, HPRT1). Shown are Mean ± SEM of relative expression values. Significant differences (P < 0.05) are in bold face.

Assay	Relative mRNA Expression NC (N = 55)	Relative mRNA Expression MDD (N = 45)	F	df	P
ADAR1 V1, 2, 3, 4, 5	1.09 ± 0.02	1.14 ± 0.03	1.73	96	0.191
ADAR1 V1, 2, 4, 5	1.01 ± 0.01	0.96 ± 0.01	2.76	96	0.007
ADAR1 V1, 4, 5	0.94 ± 0.02	0.92 ± 0.02	0.63	96	0.532
ADAR1 V2, 3	1.03 ± 0.03	0.97 ± 0.04	1.19	96	0.239
ADAR1 V4	1.05 ± 0.02	1.07 ± 0.02	0.55	96	0.584
ADAR2 V1, 4	1.20 ± 0.03	0.99 ± 0.03	4.66	96	0.000
ADAR2 V2, 3	1.17 ± 0.03	1.03 ± 0.03	3.88	96	0.000