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Ipsen 5i rescued the cell surface expression of intracellularly retained mutant MC4Rs in HEK293 cells as visualized by confocal microscopy. HEK293 cells stably expressing WT or mutant MC4Rs were treated with 10−6 M Ipsen 5i for 24 h and then stained with Alexa Fluor 488-conjugated antibody. Cells were visualized using a Nikon A1 confocal microscope. Results are representative of three independent experiments.
