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Ipsen 5i rescued the function of intracellularly retained mutant MC4Rs in N1E-115 cells. N1E-115 cells transiently expressing WT or mutant MC4Rs were treated with 10−6 M Ipsen 5i or DMSO as control. The results are expressed as % DMSO-treated WT cAMP production after correction of the cAMP production in cells expressing the empty vector. Results are shown as mean ± SEM of at least three independent experiments. See the legend to Figure 5 for details.
