Table 7.
Lexical mapping to ATC and MeSH for 13 clinically relevant drug classes
| DDI class | ATC class lexical match | MeSH class lexical match | Best corresponding class in ATC | Best corresponding class in MeSH |
|---|---|---|---|---|
|
Triptans |
- |
Tryptamines (D014363) |
Selective serotonin (5HT1) agonists (N02CC) |
- |
|
Proton pump inhibitors |
Proton pump inhibitors (A02BC) |
Proton pump inhibitors (D054328) |
- |
2-Pyridinylmethylsulfinyl-benzimidazoles (D053799) |
|
HMG CoA reductase inhibitors |
HMG CoA reductase inhibitors (C10AA) |
Hydroxymethylglutaryl-CoA Reductase Inhibitors (D019161) |
- |
- |
|
Tricyclic antidepressants |
- |
Antidepressive agents, Tricyclic (D000929) |
Non-selective monoamine reuptake inhibitors (N06AA) |
- |
|
Protease inhibitors |
Protease inhibitors (J05AE) |
Protease inhibitors (D011480) |
- |
HIV Protease inhibitors (D017320) |
|
Narcotic analgesics |
- |
Narcotics (D009294) |
OPIOIDS (N02A) |
- |
|
Selective serotonin reuptake inhibitors (SSRIs) |
Selective serotonin reuptake inhibitors (N06AB) |
Serotonin uptake inhibitors (D017367) |
Selective serotonin reuptake inhibitors (N06AB) |
Serotonin uptake inhibitors (D017367) |
|
MAO inhibitors |
MAO inhibitors (C02KC) |
Monoamine oxidase inhibitors (D008996) |
Monoamine oxidase inhibitors, non-selective (N06AF) |
Benzylamines (D001596) |
|
Macrolides |
Macrolides (J01FA) |
Macrolides (D018942) |
Macrolides (J01FA) |
Macrolides (D018942) |
|
Azoles |
- |
Azoles (D001393) |
Imidazole and triazole derivatives (D01AC) |
- |
|
Amphetamine derivatives |
- |
Amphetamines (D000662) |
- |
- |
|
Ergot alkaloids and derivatives |
Ergot alkaloids (C04AE, G02AB, N02CA) |
Ergot Alkaloids (D004876) |
- |
Ergotamines (D004879) |
| QT prolonging agents | - | - | - | - |
Lexical mapping to ATC and MeSH (columns 2-3) for 13 clinically relevant drug classes, along with their corresponding class in the other source obtained through instance-based mapping (columns 4-5). Italicized classes denote best corresponding pairs of classes.