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. Author manuscript; available in PMC: 2014 Aug 4.
Published in final edited form as: Neurobiol Aging. 2012 Mar 23;33(8):1849.e5–1849.18. doi: 10.1016/j.neurobiolaging.2012.02.014

Fig. 5.

Fig. 5

Manhattan plot of genome-wide association studies (GWAS) in human aging. Chromosomal position is shown on the x-axis versus -log10 GWAS p value on the y-axis. The threshold for genome-wide significance (p = 1.04 × 10−7) and p value threshold (p = 5 × 10−5) are indicated by the horizontal lines. Single nucleotide polymorphisms (SNPs) between these thresholds show “suggestive” associations. The 5 SNPs (highlighted by circles) exhibit significant differences in allele frequencies between samples from Mayo and Washington University (WashU) (see Fig. 4). Two of the 5 SNPs (rs4110518 and rs2944476) showed spurious genome-wide significant signals as a result of this bias.