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. Author manuscript; available in PMC: 2014 Aug 4.
Published in final edited form as: Curr Med Chem. 2010;17(14):1468–1486. doi: 10.2174/092986710790980005

Fig. (3).

Fig. (3)

The AEA/R* complex in the TMH2-3-6-7 region of CB1 R* is illustrated here. AEA (5) is shown in tube display. K3.28 forms a hydrogen bond with the amide oxygen of 5. At the same time, the head group hydroxyl of 5 is engaged in an intramolecular hydrogen bond with its amide oxygen. The AEA binding pocket is lined with residues that are largely hydrophobic, including L3.29, V3.32, F6.60, F7.35, A7.36, Y6.57, S7.39 (hydrogen bonded back to its own backbone carbonyl oxygen) and L7.43. F3.25 has a C-H•••π interaction with the C5-C6 double bond of 5; while, F2.57 has an interaction with the amide oxygen of 5 [169].