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. Author manuscript; available in PMC: 2014 Aug 4.
Published in final edited form as: Mutat Res. 2011 Jun 15;728(0):47–66. doi: 10.1016/j.mrrev.2011.06.001

Figure - 4. Effect of DIM on the MAPK signaling mechanisms.

Figure - 4

This pathway has been shown to be inhibited by DIM; these kinases transduce the signal by phosphorylating downstream protein kinases. Some of the phosphorylated signaling molecules translocate to the nucleus to activate transcription factors (such as AP-1) which regulate the expression of select set of genes.