Warts |
Topical |
Efficacious as 5%, 10% zinc sulphate lotion, 20% zinc oxide paste, and 2% intralesional zinc sulphate injection. |
[6, 7, 11] |
Oral |
10 mg/kg/day oral zinc sulphate for 2 months was an effective modality for recalcitrant warts. |
[9, 10] |
|
Cutaneous leishmaniasis |
Intralesional |
Clinical cure with 2% intralesional zinc sulphate was comparable to meglumine antimoniate. |
[12] |
Oral |
Oral zinc sulphate in doses of 2.5, 5, and 10 mg/kg/day for 45 days was an effective and safe treatment option. |
[13] |
|
Leprosy |
Oral |
Rapid clinical improvement in leprosy lesions and erythema nodosum leprosum seen on addition of oral zinc along with MDT. |
[15, 16] |
|
Herpes genitalis |
Topical |
Topical 1%, 2%, and 4% zinc sulphate for 3 months was effective in treating and preventing recurrences of herpes genitalis. |
[18] |
|
Dermatophytoses |
Topical |
20% zinc-undecylenate powder applied twice daily for 4 weeks showed clinical improvement in tinea pedis. |
[19] |
|
Bromhidrosis |
Topical |
Topical 15% zinc sulphate solution was efficacious in management of bromhidrosis and foot malodour. |
[20, 21] |
|
Pityriasis versicolor |
Topical |
Topical 15% zinc sulphate solution applied once daily for 3 weeks was effective in pityriasis versicolor. |
[22] |
|
Acne vulgaris |
Topical |
Topical 5% zinc sulphate was effective in mild to moderate acne. |
[34, 36] |
Oral |
Oral zinc sulphate and zinc gluconate were useful in moderate to severe acne. |
[37–40] |
|
Rosacea |
Oral |
Oral zinc sulphate 100 mg thrice a day was effective in rosacea after 3 months of therapy. |
[48] |
|
Hidradenitis suppurativa |
Oral |
Oral zinc gluconate 90 mg/day showed significant clinical improvement. |
[50] |
|
Psoriasis and psoriatic arthritis |
Topical |
Topical 0.25% zinc pyrithione applied twice daily was found useful in plaque psoriasis. |
[52] |
Oral |
Oral zinc sulphate was efficacious in psoriatic arthritis. |
[53] |
|
Eczemas |
Topical |
Zinc oxide paste and zinc sulphate were effective in diaper dermatitis and hand eczemas. |
[57] |
|
Ulcers |
Topical |
Topical zinc oxide paste induced rapid healing of vascular and leprosy ulcers. |
[60–62] |
Oral |
No role of systemic zinc sulphate noted in leg ulcers. |
[59] |
|
Behcet's disease and oral aphthae |
Oral |
Oral zinc sulphate 100 mg/day was an effective in oral aphthosis and Behcet's disease. |
[63, 64] |
|
Alopecia areata |
Oral |
5 mg/kg/day of oral zinc sulphate induced significant hair growth after 6 months of therapy. |
[68] |
|
Oral lichen planus |
Topical |
0.2% zinc mouthwash with fluocinolone was effective in oral lichen planus. |
[72] |
|
Xeroderma pigmentosum |
Topical |
20% zinc sulphate solution applied twice daily cleared the solar keratoses and small malignancies. |
[73] |
|
Actinic keratoses |
Topical |
25% zinc sulphate solution applied twice daily for 12 weeks cleared majority of the lesions. |
[74] |
|
Basal cell carcinoma |
Intralesional |
Intralesional 2% zinc gluconate was efficacious in basal cell carcinoma. |
[75] |
|
Vitiligo |
Oral |
Oral zinc sulphate showed moderate efficacy when given as an adjuvant with topical steroids. |
[78] |
|
Melasma |
Topical |
10% zinc sulphate solution applied twice daily for 3 months showed significant reduction in MASI score. |
[79] |
|
Keloids |
Topical |
Locally applied zinc tape showed significant clearing and reduction in relapses of keloids. |
[82, 83] |
|
Antiageing |
Topical |
0.1% copper-zinc malonate cream applied twice daily for 8 weeks showed significant reduction of wrinkles. |
[84] |