Table 3.
Subset of the Functional Categories of Biological Functions and Diseases Associated with the 197 Genes, Which Are Differentially Expressed (≥2-Fold Difference, P≤0.01) Between the Intermediate and Outer Interzones with Specific Focus on Those Functions and Diseases That Have Known Relevance for the Musculoskeletal System or Inflammation
| Functional/disease top category | P-value range | Molecule count |
|---|---|---|
| Functions | ||
| Musculoskeletal functions | ||
| Cellular development | 7.25E-09–4.44E-03 | 80 |
| Connective tissue development and function | 6.82E-08–4.51E-03 | 42 |
| Embryonic development | 6.82E-08–4.41E-03 | 64 |
| Organ development | 6.82E-08–4.41E-03 | 57 |
| Skeletal and muscular system development and function | 6.82E-08–4.51E-03 | 50 |
| Cellular movement | 1.29E-07–3.54E-03 | 51 |
| Cellular growth and proliferation | 1.47E-06–3.76E-03 | 72 |
| Cell-to-cell signaling and interaction | 2.58E-06–3.54E-03 | 56 |
| Cell signaling | 3.35E-06–4.00E-03 | 36 |
| Hematopoiesis | 3.69E-06–3.99E-03 | 19 |
| Lymphoid tissue structure and development | 8.60E-06–4.51E-03 | 29 |
| Cell death and survival | 1.26E-05–4.44E-03 | 66 |
| Cellular assembly and organization | 3.00E-05–3.52E-03 | 19 |
| Cell morphology | 8.08E-05–3.00E-03 | 37 |
| Vitamin and mineral metabolism | 8.74E-05–4.00E-03 | 15 |
| Inflammatory functions | ||
| Immune cell trafficking | 2.58E-06–3.01E-03 | 35 |
| Humoral immune response | 3.69E-06–3.58E-03 | 12 |
| Diseases | ||
| Musculoskeletal diseases | ||
| Connective tissue disorders | 5.98E-06–4.41E-03 | 30 |
| Skeletal and muscular disorders | 5.98E-06–4.41E-03 | 37 |
| Neurological disease | 3.07E-04–4.09E-03 | 24 |
| Renal and urological disease | 4.74E-04–4.41E-03 | 12 |
| Hematological disease | 1.09E-03–4.25E-03 | 16 |
| Inflammatory diseases | ||
| Inflammatory response | 2.58E-06–3.54E-03 | 41 |
| Inflammatory disease | 5.98E-06–4.41E-03 | 33 |
| Immunological disease | 1.32E-04–4.41E-03 | 22 |
| Hypersensitivity response | 1.49E-03–1.49E-03 | 3 |
The list is sorted by statistical significance and also indicates number of molecules involved in each function/disease category.