Table 5.
List of the Top Five Functions in the Three Categories “Diseases and Disorders,” “Molecular and Cellular Functions,” and “Physiological System Development and Function” and the Top Five Pathways Associated with the 197 Genes Differentially Expressed (≥2-Fold Difference, P≤0.01) Between the Intermediate and Outer Interzones (the 91 Genes Differentially Upregulated in the Intermediate Interzone and the 106 Genes Differentially Upregulated in the Outer Interzone)
| Category | Function name | Molecules | |
|---|---|---|---|
| 15.5 OI vs. II | Physiological system development and function | Cardiovascular system development and function | 44 |
| Connective tissue development and function | 42 | ||
| Embryonic development | 64 | ||
| Organ development | 57 | ||
| Organismal development | 75 | ||
| Molecular and cellular functions | Cellular development | 80 | |
| Cellular movement | 51 | ||
| Cellular growth and proliferation | 72 | ||
| Cell-to-cell signaling and interaction | 56 | ||
| Cell signaling | 36 | ||
| Diseases and disorders | Cancer | 88 | |
| Cardiovascular disease | 35 | ||
| Inflammatory response | 41 | ||
| Gastrointestinal disease | 40 | ||
| Connective tissue disorders | 30 | ||
| Pathways | Basal cell carcinoma signaling | 7/73 | |
| Human embryonic stem cell pluripotency | 8/157 | ||
| Cardiomyocyte differentiation via BMP receptors | 3/20 | ||
| Axonal guidance signaling | 13/468 | ||
| Fc-gammaRIIB signaling in B lymphocytes | 4/59 | ||
| Up in OI | Physiological system development and function | Skeletal and muscular system development and function | 25 |
| Tissue development | 40 | ||
| Connective tissue development and function | 26 | ||
| Organismal development | 40 | ||
| Embryonic development | 36 | ||
| Molecular and cellular functions | Cellular development | 41 | |
| Cellular growth and proliferation | 36 | ||
| Cellular assembly and organization | 20 | ||
| Cellular function and maintenance | 13 | ||
| Cell morphology | 26 | ||
| Diseases and disorders | Connective tissue disorders | 17 | |
| Inflammatory disease | 9 | ||
| Skeletal and muscular disorders | 19 | ||
| Developmental disorder | 23 | ||
| Hereditary disorder | 16 | ||
| Pathways | Basal cell carcinoma signaling | 7/73 | |
| Wnt/β-catenin signaling | 7/174 | ||
| Human embryonic stem cell pluripotency | 6/157 | ||
| Cardiomyocyte differentiation via BMP receptors | 3/20 | ||
| Axonal guidance signaling | 10/468 | ||
| Up in II | Physiological system development and function | Hematological system development and function | 26 |
| Cardiovascular system development and function | 22 | ||
| Hematopoiesis | 14 | ||
| Humoral immune response | 9 | ||
| Immune cell trafficking | 24 | ||
| Molecular and cellular functions | Cellular function and maintenance | 28 | |
| Cellular movement | 28 | ||
| Lipid metabolism | 17 | ||
| Small-molecule biochemistry | 31 | ||
| Cellular development | 31 | ||
| Diseases and disorders | Inflammatory response | 28 | |
| Cardiovascular disease | 20 | ||
| Immunological disease | 19 | ||
| Hypersensitivity response | 4 | ||
| Gastrointestinal disease | 18 | ||
| Pathways | Fc-gammaRIIB signaling in B lymphocytes | 4/59 | |
| eNOS signaling | 5/152 | ||
| Nitric oxide signaling in cardiovascular system | 4/99 | ||
| B cell receptor signaling | 5/170 | ||
| Eicosanoid signaling | 3/80 |
The column “Molecules” indicates the number of differentially expressed genes of our experimental dataset, which are categorized into the respective functions. For the pathways, the ratio of experimental genes partaking in the pathway divided by the total number of genes known to participate in the pathway is specified in the “Molecules” column.
eNOS, endothelial nitric oxide synthase.