Table 1. Summary of epidemiologic studies on HIV and CHD.
Study | Year | N (HIV) | Control group | Female (%) |
Age HIV | Time period |
HIV f/u (yrs) |
Primary Result | Effect Size |
---|---|---|---|---|---|---|---|---|---|
Kaiser5 | 2002 | 4159 | Random sample Kaiser members |
0 | Mean 44 | 1996- 2001 |
4.1 | ↑ MI and CHD in HIV vs. controls |
1.5 (MI) 1.7 (CHD) |
CA Medicaid6 | 2003 | 28513 | Patients enrolled in CA Medicaid > 1 year |
27 | 46% M and 35% F age 35-44 |
1994- 2000 |
2.5 | ↑ CHD in HIV (age 18-33) vs. controls |
2.06 |
FHDH7 | 2003 | 34976 | Estimated rates from French male general population |
0 | Mean 38 | 1996- 1999 |
2.8 | ↑ MI in HIV with PI exposure >18 months vs. general population |
1.5 (PI 18-29 months) 2.9 (PI ≥ 30 months) |
Partners HIV cohort8 |
2007 | 3851 | Controls from health care system-based data registry |
30 | Median 38 |
1996- 2004 |
4.5 | ↑ incident MI in HIV vs. controls |
1.75 |
Danish HIV cohort9 |
2007 | 3953 | Population-based control group matched 95:1 on sex, age, residence |
23 | Median 37 |
1995- 2004 |
5.2 | ↑ first hospitalization for CHD in HIV on ART vs. controls |
2.12 |
FHDH10 | 2010 | 74958 | Three population- based French registries |
11 | Median 47 |
2000- 2006 |
-- | ↑ MI in HIV vs. 3 population registries |
1.5 |
Quebec RAMQ database11 |
2011 | 7053 | Control group on sex, age, entry date, duration insurance |
22 | Median 37 |
1985- 2007 |
4.2 | ↑ MI in HIV vs. 4:1 matched controls |
2.11 |
VACS cohort13 | 2013 | 27350 | Controls from VACS matched on age, race, site, calendar year |
3 | Median 49 |
2003- 2009 |
5.9 | ↑ MI in HIV vs. 2:1 matched control |
1.48 |
Kaiser14 | 2013 | 22081 | HIV-uninfected Kaiser members |
9 | 40% age 35-44 |
1996- 2009 |
4.5 | ↑ MI in HIV vs. controls |
1.4 |