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. Author manuscript; available in PMC: 2014 Aug 4.
Published in final edited form as: Cancer Cell. 2003 Jan;3(1):75–88. doi: 10.1016/s1535-6108(02)00240-4

Figure 5. Decrease in growth of Vhl-/- tumors.

Figure 5

A: Teratocarcinomas were created by injecting VhV-/-, Vhl-/-.1, and Vhl-/-.2 ES cells subcutaneously into nude mice. Vhl-/- tumors ranged in size but were considerably smaller than Vhl+/- derived tumors. B: Rate of tumor growth was measured by tumor volume for 21 days. C: Graph represents the combined results of three separate experiments in which the masses of Vhl+/+, Vhl-/-, and Vhl-/-.1 + HA-VHL tumors after 21 days of growth were measured. N values are as indicated and bars represent standard error. Vhl-/- tumors were significantly smaller than Vhl+/- derived tumors. Genetically rescued Vhl-/-.1 + HA-VHL tumors grew similarly to Vhl+/- tumors. Student t-test revealed a statistically significant difference between tumor masses, p=0.003.