Table 1.
Description and Univariate analysis of pretransplant characteristics of patients undergoing HCST (n = 51 patients).
| Characteristics | Number of Sample (%) (n=51) |
No Delirium (n=35) |
Delirium (n=16) |
Hazard Ratio (95% CI) |
P-value uncorrected |
P-value corrected |
|---|---|---|---|---|---|---|
| Age, yrs (range, 21-69) | 51 (100%) | 35 | 16 | 1.02 (0.97-1.08) | 0.38 | 0.64 |
| Mean (SD) | 52.4 (10.3) | 55.3 (11.8) | ||||
| Education, yrs (range,11-21) | 51 (100%) | 35 | 16 | 1.03 (0.87-1.23) | 0.69 | 0.85 |
| Mean (SD) | 14.2 (2.5) | 14.5 (3.6) | ||||
| Gender | 51 (100%) | 35 | 16 | 1.13 (0.39-3.25) | 0.83 | 0.90 |
| Male (reference) | 36 (71%) | 25 | 11 | |||
| Female | 15 (29%) | 10 | 5 | |||
| Diagnosis | 51 (100%) | 35 | 16 | 0.07 | 0.36 | |
| Leukemia | 11 (22%) | 10 | 1 | 0.57 (0.18-1.80) | 0.34 | |
| Lymphoma | 19 (37%) | 11 | 8 | 0.09 (0.01-0.79) | 0.03 | |
| Myeloma | 13 (25%) | 11 | 2 | 0.20 (0.04-1.02) | 0.05 | |
| Other (reference) | 8 (16%) | 3 | 5 | -- | -- | |
| Donor Type | 51 (100%) | 35 | 16 | 0.71 (0.26-1.96) | 0.51 | 0.76 |
| Autologous (reference) | 29 (57%) | 19 | 10 | |||
| Allogeneic | 22 (43%) | 16 | 6 | |||
| Stem Cell Type | 51 (100%) | 35 | 16 | 0.70 (0.24-2.03) | 0.51 | 0.76 |
| Bone marrow (reference) | 13 (25%) | 8 | 5 | |||
| Peripheral | 38 (75%) | 27 | 11 | |||
| Functional Status (KPS) | 43 (84%) | 29 | 14 | 1.03 (0.96-1.10) | 0.40 | 0.66 |
| ≤70 | 2 (5%) | 2 | 0 | |||
| 80 | 11 (26%) | 8 | 3 | |||
| 90 | 23 (53%) | 14 | 9 | |||
| 100 | 7 (16%) | 5 | 2 | |||
| HCT-CI Score | 50 (98%) | 34 | 16 | 1.17 (0.33-4.18) | 0.81 | 0.89 |
| 0-1 | 29 (58%) | 16 | 13 | |||
| 2-3 | 14 (28%) | 14 | 0 | |||
| >3 | 7 (14%) | 4 | 3 | |||
| Conditioning agents* | 51 (100%) | 35 | 16 | |||
| Number of agents (continuous) |
51 (100%) | 35 | 16 | 1.33 (0.86-2.05) | 0.20 | 0.46 |
| Total Body Irradiation | 0.94 (0.21-4.14) | 0.93 | 0.95 | |||
| No (reference) | 45 (88%) | 31 | 14 | |||
| Yes | 6 (12%) | 4 | 2 | |||
| Agent that crosses blood brain barrier** |
1.62 (0.52-5.04) | 0.41 | 0.66 | |||
| No (reference) | 18 (35%) | 14 | 4 | |||
| Yes | 33 (65%) | 21 | 12 | |||
| Neuropsychological*** | ||||||
| 3MS total | 51 (100%) | 35 | 16 | 1.04 (0.93-1.16) | 0.48 | 0.74 |
| RBANS total | 27 (53%) | 19 | 8 | 1.01 (0.97-1.04) | 0.77 | 0.89 |
| Trails A Z-score | 27 (53%) | 19 | 8 | 1.22 (0.71-2.10) | 0.47 | 0.74 |
| Trails B Z-score | 27 (53%) | 19 | 8 | 0.98 (0.73-1.31) | 0.90 | 0.92 |
| Psychiatric | ||||||
| Depression | 51 (100%) | 35 | 16 | 1.78 (0.87-3.62) | 0.11 | 0.36 |