Table 5.

Grade 3–4 Post-Induction Toxicities (n=784)

Toxicity		N	Total	%	MTX Comparison: A/B vs. C/D	AraC comparison: A/C vs. B/D
Neutropenia	Regimen A	198	192	97.0	0.8427	0.8076
	Regimen B	197	193	98.0
	Regimen C	193	189	97.9
	Regimen D	196	191	97.4
	Total	784	765	97.6
Thrombocytopenia	Regimen A	198	172	86.9	0.3025	0.0004
	Regimen B	197	190	96.4
	Regimen C	193	177	91.7
	Regimen D	196	187	95.4
	Total	784	726	92.6
Anemia	Regimen A	198	175	88.4	0.2631	0.3468
	Regimen B	197	184	93.4
	Regimen C	193	181	93.8
	Regimen D	196	181	92.3
	Total	784	721	92.0
Bacterial Sepsis	Regimen A	198	58	29.3	0.3198	0.0207
	Regimen B	197	77	39.1
	Regimen C	193	54	28.0
	Regimen D	196	66	33.7
	Total	784	255	32.5
Varicella	Regimen A	198	10	5.1	0.9604	0.1082
	Regimen B	197	10	5.1
	Regimen C	193	5	2.6
	Regimen D	196	15	7.7
	Total	784	40	5.1
Zoster	Regimen A	198	9	4.5	0.5528	<0.0001
	Regimen B	197	25	12.7
	Regimen C	193	7	3.6
	Regimen D	196	22	11.2
	Total	784	63	8.0
Fungal Stomatitis	Regimen A	198	1	0.5	0.4639	0.4817
	Regimen B	197	2	1.0
	Regimen C	193	2	1.0
	Regimen D	196	3	1.5
	Total	784	8	1.0
Allergy	Regimen A	198	28	14.1	0.8492	0.7423
	Regimen B	197	31	15.7
	Regimen C	193	33	17.1
	Regimen D	196	27	13.8
	Total	784	119	15.2
Drug Fever	Regimen A	198	2	1.0	0.9850	0.4089
	Regimen B	197	1	0.5
	Regimen C	193	2	1.0
	Regimen D	196	1	0.5
	Total	784	6	0.8
Stomatitis	Regimen A	198	44	22.2	<0.0001	0.3157
	Regimen B	197	35	17.8
	Regimen C	193	70	36.3
	Regimen D	196	67	34.2
	Total	784	216	27.6
Cortical Neurotoxicity	Regimen A	198	11	5.6	0.2117	0.1999
	Regimen B	197	13	6.6
	Regimen C	193	5	2.6
	Regimen D	196	11	5.6
	Total	784	40	5.1

MTX=methotrexate