FIG. 7.

Electrophysiological properties of hiPSC- and hESC-derived neurons. (A) Bipolar iPS2 neuron with recording microelectrode attached (Scale bar=20μm). Typical current-clamp recordings from early postnatal auditory neurons cultured in vitro (B), iPS1 (C), iPS2 (D), and H9-hESC (E) neurons. (F, G) Voltage-clamp recordings of stem cell-derived neurons reveal transient tetrodotoxin-sensitive sodium current (arrow) followed by a sustained outward potassium current evoked by membrane depolarization.