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. 2014 Jul 8;136(30):10814–10820. doi: 10.1021/ja505639u

Scheme 11. Evidence for Minor Regioisomer 35a by Thermolysis.

Scheme 11

Reagents and conditions: (a) 230 °C, 60%; (b) 1-octene, Grubbs II, CH2Cl2, reflux, 59%, E/Z = 6:1; (c) N-formyl-l-leucine, DIAD, PPh3, THF, 0 °C, 69%; (d) N-formyl-l-leucine, DIAD, PPh3, THF, 0 °C, 87%.