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. 2014 Apr 29;99(8):2763–2770. doi: 10.1210/jc.2014-1258

Figure 1.

Figure 1.

Steroidogenic pathways and disruption in 21OHD. Deficiency of CYP21A2 (black bar) impairs mineralocorticoid (aldosterone) and glucocorticoid (cortisol) production. Precursors accumulate and divert to pathways involving CYP17A1 to 19-carbon steroids dehydroepiandrosterone, androstenedione, and T (androgens). Addition of abiraterone acetate blocks CYP17A1-mediated pathways and lowers androgen production. AKR1C3, aldo-keto reductase family 1, member C3; Ang II, angiotensin II; 3βHSD2, 3β-hydroxysteroid dehydrogenase/isomerase type II; StAR, steroidogenic acute regulatory protein; SULT2A1, sulfotransferase family 2A, member 1.