Figure 1.

Pedigrees of the families studied: A) Family 1; B) Family 2; C) Family 3. The arrows indicate the proband. Individuals carrying heterozygous ACAN mutations are indicated by solid symbols whereas unaffected individuals are indicated as open symbols. The age (years) and adult height SDS is indicated for all affected individuals that have reached adult height and age (years:months), bone age (BA; years:months), and height SDS at most recent visit for all affected children who are still growing.