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. 2014 Jul 8;2014:701094. doi: 10.1155/2014/701094

Figure 6.

Figure 6

Schematic model of IL-23/IL-17 axis involved in the pathogenesis of OLP. The whole process is divided into three steps: (1) keratinocytes in OLP lesion produce a large amount of IL-23 via an unknown mechanism; (2) keratinocyte-derived IL-23 may contribute to the accumulation of Th17 cells and the overproduction of IL-17 in the local lesion of OLP; (3) IL-17 reversely induces the keratinocytes to selectively produce various inflammatory mediators, which compose the complex immune network in the inflammatory environment of OLP lesions.