FIG. 2.

Pre- and postdrug assessments of average integrated area of EMG activity for lower-extremity flexor (A) and extensor (B) musculature at fastest matched speeds. 5HT medications resulted in divergent effects on lower-extremity muscle activity. SSRIs led to significant increases in pooled flexor EMG activity (A) and 5HT antagonists led to significant decreases in pooled extensor EMG activity (B), with similar trends in overall muscle activity. *Significant difference from predrug measures; p<0.025. EMG, electromyography; SSRI, selective serotonin reuptake inhibitor; 5HT, serotonergic.