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. Author manuscript; available in PMC: 2014 Aug 4.
Published in final edited form as: Tuberculosis (Edinb). 2013 Feb 1;93(1):47–59. doi: 10.1016/j.tube.2012.11.001

Table 3.

Genes involved in the metabolism of cholesterol by M. tuberculosis and the experiments conducted for each gene.

Gene name Mtb gene number Putative function Studies performed Reference
hsd Rv1106c 3β-hydroxysteroid dehydrogenase B, C, D, E, G, H 36, 37
kstD Rv3537 ketosteroid Δ1-dehydrogenase B, C, D, E, H 38, 93
kshA Rv3526 3-Ketosteroid 9α-hydroxylase B, D, E, F, H 39, 94, 95
kshB Rv3571 3-Ketosteroid 9α-hydroxylase B, D, E, F, H 39, 94, 95
hsaA Rv3570c 3-HSA-hydroxylase B, D, E, H 40
hsaB Rv3567c 3-HSA-hydroxylase B, D, E 40
hsaC Rv3568c 2,3-dehydroxyphenyl dioxygenase B, E, F, H 41
hsaD Rv3569c 4,9-DSHA hydrolase B, E, H 96
hsaE Rv3536c hydratase A, E 42
hsaF Rv3534c aldolase A, E 42
hsaG Rv3535c acetaldehyde dehydrogenase A, E 5
cyp125 Rv3545c cytochrome P450 B, D, F 50, 51, 54, 97-99
cyp142 Rv3518c cytochrome P450 B 52, 100
fadD3 Rv3561 acyl-CoA synthetase D, E
fadD17 Rv3506 acyl-CoA synthetase A,E
fadD18 Rv3513c acyl-CoA synthetase A,E
fadD19 Rv3515c acyl-CoA synthetase D, E
fadD36 Rv1193 acyl-CoA synthetase D
fadE5 Rv0244c acyl-CoA dehydrogenase D, E
fadE14 Rv1346 acyl-CoA dehydrogenase E
fadE17 Rv1934c acyl-CoA dehydrogenase E 54, 55, 99
fadE18 Rv1933c acyl-CoA dehydrogenase E 54, 55, 99
fadE25 Rv3274c acyl-CoA dehydrogenase D
fadE26 Rv3504 acyl-CoA dehydrogenase E
fadE27 Rv3505 acyl-CoA dehydrogenase E
fadE28 Rv3544c acyl-CoA dehydrogenase B, C, D, E, F 54, 55, 99
fadE29 Rv3543c acyl-CoA dehydrogenase B, C, D, E, F 54, 55, 99
fadE30 Rv3560c acyl-CoA dehydrogenase D, E
fadE31 Rv3562 acyl-CoA dehydrogenase D, E
fadE32 Rv3563 acyl-CoA dehydrogenase D, E
fadE33 Rv3564 acyl-CoA dehydrogenase D, E
fadE34 Rv3573c acyl-CoA dehydrogenase D, E
echA9 Rv1071c (S)-enoyl-CoA hydratase D
echA19 Rv3516 (S)-enoyl-CoA hydratase E, G
echA20 Rv3550 (S)-enoyl-CoA hydratase E
Rv3541c (R)-enoyl-CoA hydratase C, D, E, F 54, 55, 99
Rv3542c (R)-enoyl-CoA hydratase C, D, E, F 54, 55, 99
fadA5 Rv3546 thiolase B, C, D, E, F 34
fadA6 Rv3556c thiolase E
A

. Bioinformatic annotation

B

. Recombinant expression and enzymatic function confirmed

C

. Function examined with mutant strain in vivo

D

. Required for growth on cholesterol 35

E

. Upregulated by cholesterol 34

F

. Growth phenotype in vivo

G

. No growth phenotype in vivo

H

. Growth phenotype in macrophages 101