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. 2014 Aug 4;9(8):e102958. doi: 10.1371/journal.pone.0102958

Figure 2. The AMPA/kainate receptors GLR-1 and GLR-2 are part of the neuronal pathway but are not required for dopamine modulation of octanol response.

Figure 2

glr-1 and glr-2 code for AMPA/kainate ionotropic glutamate receptor subunits expressed in premotor interneurons of the octanol avoidance circuit. (A) glr-1 is not required for dopamine sensitivity. glr-1 (n2461) is a nonsense mutation resulting in a genetic null [26], and glr-1 (ky176) is a Tc1 excision allele with dominant negative properties [27]. (B) glr-2 is not required for dopamine sensitivity. glr-2 refers to ak10, a deletion allele [40]. (C) glr-1 glr-2 double mutants are resistant to exogenous dopamine. glr-1 glr-2 is a double mutant of the ky176 and ak10 alleles. Also see Fig. 1 legend for technical details. **p<0.001; ***p<0.0001; n.s., not significant.