Figure 1.

Effect of sildenafil on kidney histopathological picture of gentamicin-induced nephrotoxicity in rats (H&E ×400). A representative photomicrograph of a section in the kidney cortex of (a) and (b) control and sildenafil-treated groups, respectively, showing normal structure of renal glomerulus (G) and renal tubules, (c) gentamicin-treated group showing degeneration and necrobiosis in the epithelial cells lining the renal tubules (T), with apoptotic morphology with pyknotic nuclei in some cells of the renal glomerulus and tubules (arrows) and cystic luminal dilatation in some tubules (inset), and (d) gentamicin- and sildenafil-treated group showing regular epithelial cells lining the tubules with normal morphology of renal cortex.