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Superposition of 1r1h (cyan), NEPv (yellow) and 2yb9 (violet), illustrating flexibility of size and shape of S1’ and S2’ subsites. Protein surfaces of each complex are shown: A) 1r1h B) NEPv C) 2yb9. The inner parts of the S1’ and S2’ sub pockets will probably not be accessible in NEPv.
