TABLE 1.
Amino acid sequence homology between components in the CFP-10/ESAT-6 and Rv0287/Rv0288 secretion pathwaysa
| CFP-10/ESAT6 pathway component(s) | Rv0287/Rv0288 pathway component | Description and/or possible function (reference[s]) | % Homology |
|---|---|---|---|
| Rv3868 | Rv0282 | Members of CbxX/CfqX protein family; ATP binding (6, 23) | 38 |
| Rv3869 | Rv0283 | Transmembrane proteins (6, 23) | 37 |
| Rv3870, Rv3871 | Rv0284 | Dimeric membrane-bound ATPases of the FtsK family (6, 23) | 33, 33 |
| Rv3872 | Rv0285 | PE proteins (TubercuList) | 32 |
| Rv3873 | Rv0286 | Cell wall-associated PPE proteins (12, 14) | 35 |
| CFP-10 | Rv0287 | ESAT-6 proteins; secreted antigens (3, 20) | 31 |
| ESAT-6 | Rv0288 | ESAT-6 proteins; secreted antigens (20, 22) | 29 |
| Rv3877 | Rv0290 | Putative transmembrane transporter proteins (23) | 28 |
| Rv3883c | Rv0291 | Serine proteases (6, 8) | 44 |
a
Protein sequence comparisons were performed by BLASTP at the genome project website (http://genolist.pasteur.fr/TubercuList/).