Figure 5.

No difference in colon architecture and inflammation was observed between LysMCre^+/−/Il-6r^fl/fl mice and their littermate controls in acute DSS-induced colitis. Hematoxylin and eosin (H&E) staining of unchallenged and DSS-treated LysMCre^+/−/Il-6r^fl/fl mice and their littermate controls. Swiss-rolls of the colons of unchallenged mice were stained with H&E and compared to swiss-rolls of the colon of mice at the end of the experimental period of acute DSS-induced colitis. The upper 2 panels show an overview of the complete colon (magnification, ×4), bar of 300 μm; the lower 2 panels show a magnification of the rectum (magnification, ×40), bar of 50 μm. Immunohistochemistry was performed as described in Materials and methods.