Table II.
Hemodynamic changes after 10 min of Pyr-AP13 infusion (10 μg) in the sham-operated rats and H-HF rats.
| Sham-operated rats | H-HF rats | |||
|---|---|---|---|---|
|
|
|
|||
| Parameter | 5% GS (n=8) | Pyr-AP13 (n=8) | 5% GS (n=8) | Pyr-AP13 (n=8) |
| HR (bpm) | 369.2±5.5 | 372.6±4.2 | 366.4±6.1 | 364.5±5.8 |
| mLVSP (mmHg) | 129.8±17.4 | 102.2±14.6a | 184.6±20.5 | 155.7±16.3a |
| mLVDP (mmHg) | 5.2±0.8 | 4.3±0.5 | 12.8±0.8 | 10.1±0.9a |
| + dP/dtmax (mmHg/sec) | 3400.3±324.9 | 4247.5±325.6a | 2359.1±185.2 | 2977.5±266.4a |
| − dP/dtmax (mmHg/sec) | −3391.8±317.1 | −4609.0±213.5a | −2601.3±241.6 | −3064.4±166.7a |
a
P<0.05, compared with the animals that received an injection of 5% glucose injection (GS).
H-HF, hypertension with heart failure; HR, heart rate; mLVSP, mean left ventricular systolic pressure; mLVDP, mean left ventricular diastolic pressure; dp/dtmax, rate of left ventricular pressure.