Table 3. Top 12 annotated differentially methylated loci comparing individuals age >60 vs. <60.
| Probe ID | Gene | Probe location/CGI? | Avg β value: Age >60 | Avg β value: Age <60 | Avg M value: Age >60 | Avg M value: Age <60 |
|---|---|---|---|---|---|---|
| cg19731612 | NSD1 | TSS1500/Y | 0.84 | 0.75 | 2.41 | 1.57 |
| cg21823080 | CNTNAP2 | Body/N | 0.72 | 0.47 | 1.37 | –0.17 |
| cg09381737 | C9orf167 | Body/Y | 0.80 | 0.72 | 1.99 | 1.34 |
| cg10635895 | CACNA1C | Body/Y | 0.84 | 0.74 | 2.42 | 1.52 |
| cg23390118 | CACNA1C | Body/Y | 0.79 | 0.69 | 1.92 | 1.16 |
| cg07063463 | MATN4 | Body/Y | 0.71 | 0.57 | 1.30 | 0.44 |
| cg14581491 | ATF6B | Body/Y | 0.01 | 0.01 | –6.25 | –6.88 |
| cg07223935 | RPH3AL | Body/Y | 0.84 | 0.91 | 2.38 | 3.40 |
| cg21156776 | HCG26 | Body/N | 0.68 | 0.80 | 1.12 | 2.00 |
| cg20459037 | WDR16 | 3′UTR/N | 0.33 | 0.90 | –2.26 | 4.12 |
| cg21169611 | SMC2 | TSS1500/Y | 0.02 | 0.01 | –5.34 | –6.15 |
| cg07175007 | UHMK1 | TSS1500/N | 0.89 | 0.83 | 3.10 | 2.29 |
The top 12 annotated differentially methylated loci (DML) comparing individuals age >60 vs. <60 are shown. Along with the DML, the associated gene name, location, whether or not the probe is located in a CpG island (CGI: Y, yes; N, no), and β/M values are listed. TSS1500 = CpG located 1500 base pairs downstream from transcription start site; 3′UTR = CpG located in 3′untranslated region.