Figure 5. Relationship between differential methylation of CpGs and TF binding. (A) Binding of some TFs is correlated with reduced methylation level of CpGs in ER+ relative to ER- samples, while binding of others (SUZ12 and CTBP2) is correlated with increased methylation level. (B) CpGs proximal to ER binding center are more likely to have lower methylation levels in ER+ (smaller t-scores for ER+ vs. ER- comparison). (C) CpGs proximal to SUZ12 binding center are more likely to have higher methylation levels in ER+ (larger t-scores for ER+ vs. ER- comparison).