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. 2014 Jan 16;9(4):523–532. doi: 10.4161/epi.27688

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graphic file with name epi-9-523-g6.jpg — Figure 6. Correlation of CpG methylation level with expression level of the associated genes. (A) Methylation level of cg06228260 is positively correlated with its associated gene PTPRN2. (B) Methylation level of cg01586506 is negatively correlated with its associated gene SOX10. (C) Relationship between methylation-expression correlation and CpG position relative to transcription start site (from –1500 upstream to 4500 downstream of TSS). (D) Distribution of CpGs with strong correlations in methylation with expression level of the associated genes. Positive correlation (red, r > 0.4) and negative correlation (green, r < –0.4) are examined separately. (E) Fraction of CpGs strongly correlated with expression of the associated genes at different positions. (F) CpGs in ER binding regions tend to have negative correlation in their methylation with expression of their associated genes.