Table 1. Time-dependent differential modulation of human PlGF isoforms by hypoxia.

Hours	PlGF -1	PlGF-2	PlGF-3	PlGF-4
0	1	1	1	1
3	0.96 ± 0.04	1.43 ± 0.12	0.90 ± 0.02	1.18 ± 0.20
6	0.71 ± 0.12	1.10 ± 0.13	1.14 ± 0.22	1.21 ± 0.24
12	3.86 ± 0.09 *	2.73 ± 0.18 *	1.18 ± 0.27	1.00 ± 0.03
24	1.76 ± 0.28 §	1.71 ± 0.20 §	0.97 ± 0.03	1.07 ± 0.07

Data are expressed as fold induction compared with normoxic condition and represent the mean ± SEM of two independent experiments performed in triplicate. In bold the values indicating the upregulation of PlGF-1 and PlGF-2 after 12 and 24 h of exposure to 1% O₂. *P < 0.005 and ^§P < 0.05.