Table 1.

Baseline Characteristics

Characteristic	Treatment Strata
	Platinum Sensitive (n = 83)				Platinum Refractory (n = 106)
	Arm A: Ziv-Aflibercept + Topotecan (n = 42)		Arm B: Topotecan (n = 41)		Arm A: Ziv-Aflibercept + Topotecan (n = 55)		Arm B: Topotecan (n = 51)
	No.	%	No.	%	No.	%	No.	%
Median age, years	63.4		60.1		60.9		63.6
Sex
M	17	40	13	32	26	47	34	67
F	25	60	28	68	29	53	17	33
Ethnicity
White	36	86	40	98	49	89	43	84
Black	4	10	1	2	3	5	4	8
Pacific Islander	1	2	0	0	0	0	0	0
Asian	0	0	0	0	0	0	1	2
Native American	0	0	0	0	2	4	1	2
Unknown/other	1	2	0	0	1	2	2	4
Metastatic disease site
Single lesion, single organ	4	10	9	22	4	7	4	8
Multiple lesions, single organ	11	26	9	22	9	16	11	22
Multiple lesions, multiple organs	25	60	22	54	41	75	34	67
None	2	5	1	2	1	2	2	4
Performance status
0	14	33	17	41	12	22	19	37
1	28	67	24	59	43	78	32	63
Stage
Extensive	27	64	23	56	39	71	42	82
Limited	15	36	18	44	16	29	9	18