Table 2.
Tumor Characteristics Stratified by Previous Diagnosis of Depressive Disorder
| Characteristic | Men Without Depressive Disorder (n = 39,381) |
Men With Depressive Disorder (n = 1,894) |
P | ||
|---|---|---|---|---|---|
| No. | % | No. | % | ||
| Grade | .03 | ||||
| Well/moderately | 16,277 | 41.3 | 736 | 38.9 | |
| Poorly/undifferentiated | 23,104 | 58.7 | 1,158 | 61.1 | |
| Clinical stage | .42 | ||||
| T1 | 20,836 | 52.9 | 1,021 | 53.9 | |
| T2 | 16,414 | 41.7 | 770 | 40.7 | |
| T3 to T4 | 1,602 | 4.1 | 71 | 3.8 | |
| Gleason score | .42 | ||||
| ≤ 6 | 15,403 | 39.1 | 691 | 36.5 | |
| 7 | 15,547 | 39.5 | 755 | 39.9 | |
| 8-10 | 8,248 | 20.9 | 438 | 23.1 | |
| Initial treatment by NCCN risk category | |||||
| Low risk | < .001 | ||||
| All treatments | 10,860 | 27.6 | 487 | 25.7 | |
| ADT | 827 | 7.6 | 47 | 9.7 | |
| RT | 5,737 | 52.8 | 219 | 45.0 | |
| Cryotherapy | 203 | 1.9 | 13 | 2.7 | |
| RP | 1,458 | 13.4 | 54 | 11.1 | |
| EM | 2,635 | 24.3 | 154 | 31.6 | |
| Intermediate risk | < .001 | ||||
| All treatments | 17,105 | 43.4 | 789 | 41.7 | |
| ADT | 2,338 | 13.7 | 152 | 19.3 | |
| RT | 8,033 | 47.0 | 330 | 41.8 | |
| Cryotherapy | 436 | 2.6 | 24 | 3.0 | |
| RP | 3,760 | 22.0 | 134 | 17.0 | |
| EM | 2,538 | 14.8 | 149 | 18.9 | |
| High risk | < .001 | ||||
| All treatments | 11,416 | 29.0 | 618 | 32.6 | |
| ADT | 3,769 | 33.0 | 236 | 38.2 | |
| RT | 4,682 | 41.0 | 207 | 33.5 | |
| Cryotherapy | 178 | 1.6 | 10 | 1.6 | |
| RP | 1,355 | 11.9 | 54 | 8.7 | |
| EM | 1,432 | 12.5 | 111 | 18.0 | |
| PSA, ng/dL | |||||
| Mean | 11.4 | 12.2 | .47 | ||
| Median | 7.1 | 7.1 | 1.0 | ||
| Days from diagnosis to treatment | |||||
| Mean | 131 | 134 | .40 | ||
| Median | 84 | 82 | 1.0 | ||
| No. of physician visits in 2 years before diagnosis | < .001 | ||||
| Mean | 26.8 | 42.7 | |||
| Median | 22 | 36 | |||
Abbreviations: ADT, androgen deprivation therapy; EM, expectant management; NCCN, National Comprehensive Cancer Network; PSA, prostate-specific antigen; RP, radical prostatectomy; RT, radiation therapy.