Table 4.

Cox Proportional Hazards Model of Overall Mortality by NCCN Risk Group

Variable	Low Risk			Intermediate Risk			High Risk
	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
Year of diagnosis (referent: 2004)
2005	0.92	0.78 to 1.08	.31	0.87	0.78 to 0.96	.01	1.03	0.95 to 1.12	.49
2006	0.86	0.71 to 1.03	.10	0.82	0.73 to 0.93	.001	0.95	0.86 to 1.04	.27
2007	0.74	0.59 to 0.93	.01	0.75	0.65 to 0.87	< .001	0.84	0.76 to 0.94	.002
Age at diagnosis, years (referent: ≥ 67-69)
70-74	1.24	1.02 to 1.51	.03	1.33	1.14 to 1.54	< .001	1.12	0.98 to 1.28	.09
≥ 75	2.11	1.74 to 2.55	< .001	1.96	1.69 to 2.27	< .001	1.65	1.47 to 1.86	< .001
Charlson score (referent: 0)
1	1.46	1.25 to 1.71	< .001	1.77	1.60 to 1.96	< .001	1.30	1.20 to 1.41	< .001
≥ 2	3.32	2.83 to 3.89	< .001	2.76	2.48 to 3.07	< .001	2.00	1.84 to 2.17	< .001
Race/ethnicity (referent: Asian)
Non-Hispanic white	1.28	0.82 to 2.02	.28	1.20	0.92 to 1.57	.18	1.53	1.24 to 1.89	< .001
Black	1.86	1.15 to 3.03	.01	1.23	0.91 to 1.65	.17	1.67	1.32 to 2.11	< .001
Hispanic	1.19	0.71 to 1.99	.51	0.88	0.63 to 1.21	.42	1.18	0.92 to 1.52	.19
Marital status (referent: married)
Not married	1.26	1.09 to 1.46	.001	1.32	1.20 to 1.45	< .001	1.29	1.20 to 1.39	< .001
Percentage with high school education (referent: ≥ 90)
< 75	1.19	0.92 to 1.55	.18	1.03	0.87 to 1.22	.73	1.16	1.02 to 1.33	.02
75-84.99	1.09	0.87 to 1.36	.44	1.00	0.86 to 1.15	.95	1.04	0.93 to 1.17	.46
85-89.99	0.99	0.80 to 1.22	.89	1.04	0.91 to 1.20	.54	1.04	0.93 to 1.16	.48
Median household income, $ (referent: ≥ 60,000)
< 35,000	1.13	0.84 to 1.50	.43	1.52	1.25 to 1.85	< .001	1.11	0.95 to 1.30	.18
35,000-44,999	1.16	0.90 to 1.50	.26	1.39	1.17 to 1.66	< .001	1.21	1.06 to 1.39	.006
45,000-59,999	1.13	0.90 to 1.44	.30	1.17	0.99 to 1.39	.07	1.14	1.00 to 1.30	.05
SEER registry site (referent: Atlanta)
San Francisco	0.38	0.21 to 0.69	.002	0.54	0.37 to 0.77	.001	1.00	0.78 to 1.29	1.00
Connecticut	0.84	0.55 to 1.29	.42	0.66	0.49 to 0.89	.007	0.86	0.69 to 1.09	.22
Michigan	1.01	0.67 to 1.51	.98	0.91	0.70 to 1.20	.52	0.93	0.74 to 1.17	.52
Hawaii	1.15	0.54 to 2.44	.72	1.02	0.66 to 1.58	.93	1.08	0.75 to 1.55	.67
Iowa	0.93	0.60 to 1.47	.77	0.76	0.56 to 1.03	.08	1.06	0.84 to 1.35	.63
New Mexico	0.77	0.42 to 1.41	.39	0.82	0.57 to 1.18	.28	1.05	0.76 to 1.44	.77
Seattle	0.65	0.41 to 1.03	.06	0.73	0.54 to 0.98	.04	0.88	0.69 to 1.12	.30
Utah	0.77	0.46 to 1.30	.33	0.91	0.66 to 1.26	.56	1.15	0.86 to 1.53	.36
San Jose	0.98	0.60 to 1.60	.93	0.70	0.48 to 1.01	.06	0.88	0.67 to 1.17	.39
Los Angeles	0.73	0.48 to 1.13	.16	0.79	0.59 to 1.06	.12	1.00	0.79 to 1.26	.97
Greater California	0.72	0.49 to 1.05	.09	0.65	0.50 to 0.85	.001	0.90	0.73 to 1.12	.34
Kentucky	0.96	0.62 to 1.46	.84	0.69	0.51 to 0.93	.02	1.11	0.87 to 1.41	.39
Louisiana	0.87	0.58 to 1.29	.48	0.82	0.62 to 1.08	.16	0.89	0.71 to 1.11	.30
New Jersey	0.73	0.50 to 1.06	.10	0.79	0.61 to 1.03	.09	0.89	0.71 to 1.10	.27
Population density (referent: metropolitan)
Nonmetropolitan	0.98	0.76 to 1.25	.85	1.09	0.93 to 1.28	.26	0.91	0.80 to 1.03	.13
Grade (referent: poorly/undifferentiated)
Well/moderately	0.80	0.52 to 1.23	.31	0.87	0.79 to 0.96	.006	0.59	0.53 to 0.67	< .001
Previous depressive disorder diagnosis (referent: no)
Yes	1.86	1.48 to 2.33	< .001	1.25	1.06 to 1.49	.01	1.16	1.03 to 1.32	.02
Treatment (referent: EM)
RP	0.49	0.36 to 0.66	< .001	0.30	0.25 to 0.36	< .001	0.23	0.19 to 0.28	< .001
RT	0.67	0.58 to 0.78	< .001	0.52	0.47 to 0.58	< .001	0.41	0.37 to 0.46	< .001
ADT	1.01	0.82 to 1.25	.91	1.07	0.95 to 1.20	.27	1.05	0.96 to 1.15	.25

Abbreviations: ADT, androgen deprivation therapy; EM, expectant management; HR, hazard ratio: NCCN, National Comprehensive Cancer Network; RP, radical prostatectomy; RT, radiation therapy.