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Case study, trial one: phase I trial of platelet-derived growth factor receptor inhibitor imatinib mesylate and docetaxel in patients with prostate cancer. (A) Trial history (dose units are in mg/m2); (B) observed dose-limiting toxicity (DLT) rate at each dose level. Brackets indicate maximum-tolerated dose; squares indicate DLTs; circles indicate observed DLT rate; dashed line indicates acceptable/target DLT rate. Data adapted.35
