Table 2.
SNP interaction results.
| SNP | ADNI-1 dataset | ADNI2/GO dataset | Combined datasets | |||
|---|---|---|---|---|---|---|
| t | p-value | t | p-value | t | p-value | |
| AMYLOID INTERACTIONS ON INTERCEPT | ||||||
| rs6887649 (FTMT) | 4.95 | 1.50 × 10−6 | −0.13 | 0.899 | 5.68 | 1.99 × 10−8* |
| AMYLOID INTERACTIONS ON SLOPE | ||||||
| rs7849530 (SPTLC1) | 4.52 | 8.00 × 10−6 | 2.64 | 0.009 | 6.40 | 2.89 × 10−10* |
| rs4866650 | 3.89 | 0.0001 | 2.28 | 0.023 | 6.15 | 1.35 × 10−9* |
| TAU INTERACTIONS ON SLOPE | ||||||
| rs12261764 (WDR11-AS1) | 4.54 | 8.00 × 10−6 | 3.18 | 0.002 | 5.55 | 9.5 × 10−8* |
*
Significant when correcting for multiple comparisons (Bonferroni < 0.05).