Fig. 2.

Class I HDAC inhibition potentiates renal dysfunction and damage in the murine model of folic acid (FA)- or rhabdomyolysis (RM)-induced acute kidney injury (AKI). After various treatments as indicated, blood was collected and the serum creatinine and blood urea nitrogen (BUN) were measured (A–D). The kidneys underwent periodic acid-Schiff (PAS) staining (E). Morphological changes were scored based on the scale described in materials and methods (F). Data are represented as means ± SE (n = 6). Means with different superscript letters are significantly different from one another (P < 0.05).